Protein Details: Potassium voltage-gated channel subfamily KQT member 5
Protein ID
ICDB_Pro_1582
Protein Name
Potassium voltage-gated channel subfamily KQT member 5
Gene Name
KCNQ5
Organism
Homo sapiens (Human)
Length
932 amino acids
AlphaFoldDB
AF-Q9NR82-F1-model_v4.pdb
Function
Associates with KCNQ3 to form a potassium channel which contributes to M-type current;a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore;it is important in the regulation of neuronal excitability. May contribute;with other potassium channels;to the molecular diversity of a heterogeneous population of M-channels;varying in kinetic and pharmacological properties;which underlie this physiologically important current. Insensitive to tetraethylammonium;but inhibited by barium;linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel;the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1
Sequence
PDB Structures
Ligand Binding
Binding Site
Disease
Intellectual Developmental Disorder;Autosomal Dominant 46 and Autosomal Dominant Non-Syndromic Intellectual Disability
Location
subregions of the brain and in skeletal muscle
DOI ID
10.1074/jbc.m002378200; 10.1038/nature02055; 10.1101/gr.2596504; 10.1038/ng1285; 10.1074/jbc.m003245200; 10.1038/sj.bjp.0703861; 10.1021/pr300630k; 10.1161/atvbaha.114.303801; 10.1016/j.neuron.2018.01.035; 10.1126/science.1133427; 10.1016/j.ajhg.2017.05.016
RefSeq
NP_001153602.1 [Q9NR82-2]; NP_001153604.1 [Q9NR82-3]; NP_001153605.1 [Q9NR82-6]; NP_001153606.1 [Q9NR82-5]; NP_062816.2 [Q9NR82-1]